{"title":"L-Methionine","description":"\u003ch2 data-start=\"539\" data-end=\"592\" style=\"text-align: center;\"\u003e\u003cstrong data-start=\"539\" data-end=\"592\"\u003eL-Methionine for Liver Health \u0026amp; Cellular Wellness\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"694\" data-end=\"1009\" style=\"text-align: center;\"\u003eL-Methionine is an essential amino acid that plays a key role in supporting \u003cstrong data-start=\"770\" data-end=\"788\"\u003eliver function\u003c\/strong\u003e, \u003cstrong data-start=\"790\" data-end=\"817\"\u003edetoxification pathways\u003c\/strong\u003e, and \u003cstrong data-start=\"823\" data-end=\"842\"\u003ecellular health\u003c\/strong\u003e. It serves as a precursor to important compounds involved in antioxidant production and methylation processes, which help protect cells and support metabolic balance.\u003c\/p\u003e\n\u003cp data-start=\"1011\" data-end=\"1332\" style=\"text-align: center;\"\u003eThis collection features high quality \u003cstrong data-start=\"1049\" data-end=\"1077\"\u003eL-Methionine supplements\u003c\/strong\u003e, including capsules and powders formulated to support liver wellness, antioxidant defense, and overall metabolic function. L-Methionine is commonly used in wellness routines focused on detox support, cellular protection, and long term health maintenance.\u003c\/p\u003e\n\u003cp data-start=\"1334\" data-end=\"1596\" style=\"text-align: center;\"\u003eOften stacked with cysteine, glutathione, or B-vitamins, L-Methionine supplements provide non-stimulant support for foundational cellular processes. These formulas are ideal for individuals seeking targeted amino acid support for liver health and detoxification.\u003c\/p\u003e\n\u003cp data-start=\"1598\" data-end=\"1710\" style=\"text-align: center;\"\u003e\u003cstrong data-start=\"1598\" data-end=\"1631\"\u003eShop L-Methionine supplements\u003c\/strong\u003e formulated to support liver function, detox pathways, and cellular resilience.\u003c\/p\u003e","products":[{"product_id":"controlled-labs-purple-wraath","title":"Purple Wraath","description":"\u003cp style=\"text-align: center;\"\u003e\u003cspan style=\"font-size: 10pt; color: #000000;\"\u003eTHIS PRODUCT HAS BEEN DISCONTINUED.  \u003ca href=\"https:\/\/www.tigerfitness.com\/pages\/search-results-page?q=eaa\"\u003eClick Here\u003c\/a\u003e for more options!\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-size: 10pt; color: #000000;\"\u003e \u003c\/span\u003e\u003cspan style=\"color: #000000;\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv align=\"center\"\u003e\u003cspan style=\"font-size: 14pt; color: #000000;\"\u003e\u003cstrong\u003eControlled Labs Purple Wraath | Now on sale at TigerFitness\u003c\/strong\u003e\u003cbr\u003e\u003c\/span\u003e\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eDiscover the \"Holy Grail\" of bodybuilding and athletic performance enhancement:\u003c\/span\u003e maximizing lean gains and fat loss while enhancing recovery and increasing strength, endurance, and energy. Purple Wraath was created to be the most complete EAA\/BCAA product on the market; keeping your body in a constant anabolic state and keeping you training hard with its added super endurance complex.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold; font-size: 12pt; color: #000000;\"\u003eKey Attributes:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eFast absorption\/fast acting\u003c\/li\u003e\n\u003cli\u003eEAA \u0026amp; BCAA\u003c\/li\u003e\n\u003cli\u003eCaffeine-free ergogenic formula\u003c\/li\u003e\n\u003cli\u003eDelicious tangy grape flavor\u003c\/li\u003e\n\u003cli\u003eNatural anabolic environment\u003c\/li\u003e\n\u003cli\u003eIncrease athletic performance, endurance, focus, stamina, and muscle recovery\u003c\/li\u003e\n\u003cli\u003eLegal, safe, and effective for both men and women\u003c\/li\u003e\n\u003cli\u003eStimulate metabolism to reduce body fat\u003c\/li\u003e\n\u003cli\u003eExplosive strength, power, and energy\u003c\/li\u003e\n\u003cli\u003eIncrease or maintain muscle mass whether cutting or bulking\u003c\/li\u003e\n\u003cli\u003eDextrose\/maltodextrin free\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eSound too good to be true? Keep reading...\u003c\/p\u003e\n\u003cp\u003eWe all know that supplements are not a replacement for nutrition and training, but if you are looking for a supplement to enhance every part of your workout and take your gains to the next level... look no further than Purple Wraath by Controlled Labs.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold; font-size: 12pt; color: #000000;\"\u003ePurplEAA Complex:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eThe Purple Wraath PurplEAA Complex is a very efficient formula based on the science of actual homo sapiens muscle protein and clinical studies on human amino acid assimilation. Essential Amino Acids (EAA's) are the \"building blocks\" of lean muscle mass, but the EAA's from whey protein can take hours to enter circulation. The solution is the Purple Wraath fast-acting, free-form PurplEAA Complex:\u003c\/p\u003e\n\u003cp\u003eWhile essential amino acids function cohesively as a group to aid in your training, additionally they each produce a significant benefit when it comes to training:\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eLeucine:\u003c\/span\u003e\u003cbr\u003e- Primary anabolic trigger\u003cbr\u003e- Enhance recovery\u003cbr\u003e- Optimize hormone levels\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eValine:\u003c\/span\u003e\u003cbr\u003e- Energy \u003cbr\u003e- Recovery \u003cbr\u003e- Glucose production \u003cbr\u003e- Nitrogen balance\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eIsoleucine:\u003c\/span\u003e \u003cbr\u003e- Energy \u003cbr\u003e- Recovery \u003cbr\u003e- Glucose production \u003cbr\u003e- Hormones\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eLysine:\u003c\/span\u003e\u003cbr\u003e- Beta-oxidation \u003cbr\u003e- Nitrogen balance \u003cbr\u003e- Calcium absorption \u003cbr\u003e- Energy\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eArginine:\u003c\/span\u003e \u003cbr\u003e- Vasodilator \u003cbr\u003e- Nutrient delivery \u003cbr\u003e- Anti-Catabolic\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eHistidine:\u003c\/span\u003e\u003cbr\u003e- Vasodilator \u003cbr\u003e- Sexual function\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eThreonine:\u003c\/span\u003e \u003cbr\u003e- Nutrient uptake \u003cbr\u003e- Immune system\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eMethionine:\u003c\/span\u003e \u003cbr\u003e- Enhance metabolism \u003cbr\u003e- Energy \u003cbr\u003e- Mood \u003cbr\u003e- Antioxidant\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003ePhenylalanine:\u003c\/span\u003e \u003cbr\u003e- Energy \u003cbr\u003e- Hormones \u003cbr\u003e- Mood\u003c\/p\u003e\n\u003cp\u003eIt's important to understand that our EAA Complex includes all of the BCAA's (Branched Chain Amino Acids) that you have used in the past, including a precise ratio of leucine. Research shows that blood levels of these KEY amino acids are directly related to muscle protein synthesis, so we formulated a comprehensive and efficient matrix to enhance lean mass directly and indirectly, and under various conditions. Now, that ratio is important, but there are some other very exciting points about this formula. Unlike some of the amino acid supplements on the market, you aren't paying for cheap \"filler\" ingredients such as dextrose or maltodextrin when you purchase Purple Wraath. Also, we chose not to include the amino acid glutamine since it is not an essential amino acid, and our bodies can synthesize it on its own in sufficient quantities. Because the studies that we based this formula off of do not use tryptophan and since it has the potential for \"sedative\" like side affects, we designed Purple Wraath to be completely tryptophan-free.\u003c\/p\u003e\n\u003cp\u003eBy combining intense exercise or weightlifting with the fast absorbing PurplEAA Complex you can rush nutrients into the active cells of your working muscles, creating an anabolic environment optimal for recovery and lean mass.\u003c\/p\u003e\n\u003cp\u003eWhat would an EAA product be without some amazing support ingredients? Good, but not great. To make this formula great we added the PurplEndurance Complex.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold; font-size: 12pt; color: #000000;\"\u003ePurplEndurance Complex:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eYou can't create an optimal anabolic environment without intensity so Controlled Labs decided to take things to the extreme with Purple Wraath by including the ultimate caffeine-free Ergogenic Complex:\u003c\/p\u003e\n\u003cp\u003eSo what does each of the ingredients in the PurplEndurance Complex do?\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eBeta-Alanine:\u003c\/span\u003e \u003cbr\u003e- Helps increase aerobic efficiency \u003cbr\u003e- Helps enhance oxygen transport \u003cbr\u003e- Helps to reduce lactic acid accumulation\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eCitrulline Malate:\u003c\/span\u003e \u003cbr\u003e- Reduces Lactic Acid and Ammonia \u003cbr\u003e- Boosts energy production \u003cbr\u003e- Has an oxygen sparing effect \u003cbr\u003e- Boosts mitochondrial function\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eBetaine Anhydrous:\u003c\/span\u003e \u003cbr\u003e- Is a key osmotic\/cellular hydration ingredient \u003cbr\u003e- Enhances muscle fullness \u003cbr\u003e- Acts as an energy enzyme protector \u003cbr\u003e- Induces the conversion of homocysteine to methionine \u003cbr\u003e- Elevates glutathione levels \u003cbr\u003e- Promotes liver health \u003cbr\u003e- Helps you maintain intracellular electrolytes \u003cbr\u003e- Enhances metabolism\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eGinger:\u003c\/span\u003e \u003cbr\u003e- Aids in nutrient absorption \u003cbr\u003e- Enhances digestion\/stomach function \u003cbr\u003e- Produces a nootropic effect\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eNorvaline:\u003c\/span\u003e \u003cbr\u003e- Helps elevate naturally occurring eNOS\u003c\/p\u003e\n\u003cp\u003eAs you can see, we have responded to customer demand and the result: Purple Wraath...the most advanced pre-workout product available!!\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"font-weight: bold;\"\u003eREFERENCES\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eBorsheim, E., Tipton, K., Wolf, S. \u0026amp; Wolfe, R. (2002)\u003cbr\u003eEssential amino acids and muscle protein recovery from resistance exercise\u003cbr\u003eAmerican Journal of Physiology, 283(4), E648-E657\u003c\/p\u003e\n\u003cp\u003eBrooks, G. (1987).\u003cbr\u003eAmino acid and protein metabolism during exercise and recovery \u003cbr\u003eMedicine and Science in sports and Exercise, 19(5), S150-S156\u003c\/p\u003e\n\u003cp\u003eRasmussen, B., Tipton, K., Miller, S., Wolf, S. \u0026amp; Wolfe, R. (2000)\u003cbr\u003eAn oral essential amino acid-carbohydrate supplement enhances protein anabolism after resistance exercise\u003cbr\u003eJournal of Applied Physiology, 88, 386-392\u003c\/p\u003e\n\u003cp\u003eTipton, K., Rasmussen, B., Miller, S., Wolf, S., Owens-Stovall, S., Petrini, B. \u0026amp; Wolfe, R. (2001)\u003cbr\u003eTiming of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise\u003cbr\u003eAmerican Journal of Physiology, Endocrinology, and Metabolism, 281, E197-E206\u003c\/p\u003e\n\u003cp\u003eBohe J, Low A, Wolfe RR, Rennie MJ. (2003)\u003cbr\u003eHuman muscle protein synthesis is modulated by extra cellular, not intramuscular amino acid availability: a dose-response study.\u003cbr\u003eJ Physiol552(Pt 1):315-24.\u003c\/p\u003e\n\u003cp\u003eTipton, K., Borsheim, E., Wolf, S., Sanford, A. \u0026amp; Wolfe, R. (2003)\u003cbr\u003eAcute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion \u003cbr\u003eAmerican Journal of Physiology, 284(1), E76-E79.\u003c\/p\u003e\n\u003cp\u003eMacLean, D. A., Graham, T. E. \u0026amp; Saltin, B. (1994)\u003cbr\u003eBranched-chain amino acids augment ammonia metabolism while attenuating protein breakdown during exercise.\u003cbr\u003eAm. J. Physiol. 267: E1010...E1022\u003c\/p\u003e\n\u003cp\u003eAdibi, S., Gary, S., Menden, E. (1967)\u003cbr\u003eThe kinetics of amino acid absorption and alteration of plasma composition of free amino acids after intestinal perfusion of amino acid mixtures\u003cbr\u003eAmerican Journal of Clinical Nutrition, 20, 24-33\u003c\/p\u003e\n\u003cp\u003eNosaka, K. (2003)\u003cbr\u003eMuscle soreness and amino acids.\u003cbr\u003eTraining J. 289:24-28.\u003c\/p\u003e\n\u003cp\u003eVolpi E, Sheffield-Moore M, Rasmussen BB, and Wolfe RR. (2001)\u003cbr\u003eBasal muscle amino acid kinetics and protein synthesis in healthy young and older men \u003cbr\u003eJAMA 286: 1206...1212\u003c\/p\u003e\n\u003cp\u003eHan LK, Gong XJ, Kawano S, Saito M, Kimura Y, Okuda H. \u003cbr\u003eAntiobesity actions of Zingiber officinale Roscoe \u003cbr\u003eYakugaku Zasshi. 2005 Feb;125(2):213-7\u003c\/p\u003e\n\u003cp\u003eYoung, H. V., Luo, Y. L., Cheng, H. Y., Hsieh, W. C., Liao, J. C. and Peng, W. H. (2005). \u003cbr\u003eAnalgesic and... activities of [6]-gingerol. \u003cbr\u003eJ Ethnopharmacol 96 (1): 207-210.\u003c\/p\u003e\n\u003cp\u003eDunnett M, Harris RC. \u003cbr\u003eInfluence of oral beta-alanine and L-histidine supplementation on the carnosine content of the gluteus medius \u003cbr\u003eEquine Vet J Suppl. 1999 Jul;30:499-504.\u003c\/p\u003e\n\u003cp\u003eMaynard LM, Boissonneault GA, Chow CK, Bruckner GG. \u003cbr\u003eHigh levels of dietary carnosine are associated with increased concentrations of carnosine and histidine in rat soleus muscle \u003cbr\u003eJ Nutr. 2001 Feb;131(2):287-90\u003c\/p\u003e\n\u003cp\u003eTakashi Nagasawa, Tatsuji Yonekura, Naoyuki Nishizawa and David D. Kitts \u003cbr\u003eIn vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine \u003cbr\u003eMolecular and Cellular Biochemistry 225: 29-34, 2001\u003c\/p\u003e\n\u003cp\u003eTallon MJ, Harris RC, Boobis LH, Fallowfield JL, Wise JA. \u003cbr\u003eThe carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders. \u003cbr\u003eJ Strength Cond Res. 2005 Nov;19(4):725-729\u003c\/p\u003e\n\u003cp\u003eSuzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K. \u003cbr\u003eHigh level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting \u003cbr\u003eJpn J Physiol. 2002 Apr;52(2):199-205\u003c\/p\u003e\n\u003cp\u003eBalon TW and Nadler JL. \u003cbr\u003eNitric oxide is present from incubated skeletal muscle preparations \u003cbr\u003eJ Appl Physiol 77: 2519-2521, 1994\u003c\/p\u003e\n\u003cp\u003eBalon TW and Nadler JL. \u003cbr\u003eEvidence that nitric oxide increases glucose transport in skeletal muscle \u003cbr\u003eJ Appl Physiol 82: 359-363, 1997\u003c\/p\u003e\n\u003cp\u003eWagenmakers, A. (1998). \u003cbr\u003eMuscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism \u003cbr\u003eExercise and Sport Sciences Reviews, 26, 287-314\u003c\/p\u003e\n\u003cp\u003eTipton, K. \u0026amp; Wolfe, R. (1998) \u003cbr\u003eExercise-induced changes in protein metabolism \u003cbr\u003eActa Physiology Scandinavia, 162(3), 377-387\u003c\/p\u003e\n\u003cp\u003eWolfe, R. (2001) \u003cbr\u003eEffects of amino acid intake on anabolic processes \u003cbr\u003eCanadian Journal of Applied Physiology, S26, S220-S227\u003c\/p\u003e\n\u003cp\u003eWolfe, R. (2001) \u003cbr\u003eControl of muscle protein breakdown: effects of activity and nutritional states.\u003cbr\u003eInternational Journal of Sport Nutrition and Exercise Metabolism, S11, S164-S169\u003c\/p\u003e\n\u003cp\u003eBiolo, G., Tipton, K., Klein, S. \u0026amp; Wolfe, R. (1997)\u003c\/p\u003e\n\u003cp\u003eAn abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein \u003cbr\u003eAmerican Journal of Physiology, Endocrinology, and Metabolism, 273, E122-E129\u003c\/p\u003e","brand":"1DISCONTINUED","offers":[{"title":"Juicy Grape \/ 45 Servings","offer_id":17460313358394,"sku":"3770017","price":38.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/products\/controlled-labs-purple-wraath-3770017-319341.jpg?v=1701817554"},{"product_id":"core-nutritionals-core-shred","title":"Core Shred","description":"\u003cp\u003e\u003cimg alt=\"Core Shred Banner\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/files\/core-nutritionals-shred-banner_compressed.jpg?v=1599148938\"\u003e\u003c\/p\u003e\n\u003cp\u003eIt’s late evening and you need to crush your workout worst of all, you're deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e1 scoop per serving.\u003c\/li\u003e\n\u003cli\u003e50 servings per container.\u003c\/li\u003e\n\u003cli\u003eHealthy thyroid support.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIt’s late evening and you need to crush your workout worst of all, your deep in a diet. You haven’t taken your thermogenic yet, you know you need to, but you also know that downing a few hundred milligrams of stimulants at 8 PM is not conducive to healthy sleep patterns. So, what do you do?\u003cbr\u003e\u003cbr\u003ePrior to now, you sucked it up and chugged your ultra-potent and effective stimulant based thermogenic (such as BURN Powder!) and dealt with the consequences. But as of now, you take a scoop of the ultra-potent and equally effective, non-stimulant based thermogenic Core SHRED.\u003cbr\u003e\u003cbr\u003eWe’ve taken our typical approach to product formulation proven ingredients at clinically effective and clinically-proven serving sizes and applied it to creating a comprehensive, multiple pathway non-stimulant thermogenic product. The result is a product covering major pathways of lipolysis in multiple, non-redundant, and synergistic ways, all without any neurological stimulation whatsoever.\u003cbr\u003e\u003cbr\u003eWhether you’re taking a break from stimulants, are stimulant sensitive, or simply want a non-stimulant thermogenic to stack with our excellent stimulant based offerings, Core SHRED is the perfect solution. Use it anytime, night or day, to help crush your regular exercise program and consistent diet!\u003c\/p\u003e\n\u003ch3\u003eAcetyl-l-Carnitine:\u003c\/h3\u003e\n\u003cp\u003eL-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes along with dietary sources of carnitine from protein rich red meat, for example dietary supplementation of carnitine may pose benefits in certain physiological conditions. Unfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.\u003c\/p\u003e\n\u003ch3\u003eOlive Extract (Oleaeuropaeai) (leaf) (20% oleuropein):\u003c\/h3\u003e\n\u003cp\u003eOlea europaea, more commonly known as the olive, is a species of a small tree in the family Oleaceae, native to the coastal areas of southeastern Europe, western Asia, and northern Africa, as well as northern Iran at the south end of the Caspian Sea. As the fruits, oils, and extracts of Olea europaea L. are a dietary component for a significant portion of the world’s population, the plant has become associated with a wide range of physiologic and metabolic benefits. These properties are largely attributed to the phenolic compounds of olive leaves, including caffeic acid, verbascoside, oleuropein, luteolin 7-O-glucoside, rutin, apigenin 7-Oglucoside, and luteolin 4′-O-glucoside. Collectively, these olive polyphenols are responsible for a wide range of postulated health benefits.\u003c\/p\u003e\n\u003cp\u003eOleuropein, in particular, is purported to have several pharmacological properties including antioxidant, anti-inflammatory, anti-atherogenic, and anti-microbial effects. Recent research in animals has also demonstrated that oleuropein may potentiate the response of 5'-deiodinase, the enzyme responsible for the irreversible conversion of thyroxine (T4) into triiodothyronine (T3), the active thyroid hormone.\u003c\/p\u003e\n\u003ch3\u003eColeus forskohlii root extract (20% forskolin):\u003c\/h3\u003e\n\u003cp\u003eColeus forskohlii is a small perennial endemic to various tropical regions in the world, including South America, sub-Saharan Africa, and India. While the West has recently taken interest in the plant due to the pharmacological properties of its primary bioactive, forskolin, Coleus forskholii preparations, and tinctures have been used in both South American and African traditional folk medicinal systems, as well as extensively within Ayurveda. Due to the ever increasing interest in the plant’s verifiable pharmacological and physiological effects, however, Coleus forksholii and its extracted constituents have been the subject of numerous animal and human clinical trials in the past decade. These trials have demonstrated the plant to have various effects and applications, including as a lipolytic and anti-lipogenic, and as a powerful antioxidant.\u003c\/p\u003e\n\u003cp\u003eA recent double blind, randomized, and placebo-controlled human clinical trial featuring obese men found that the daily implementation of Coleus forskholii, for twelve weeks, led to significantly better weight loss outcomes as compared to controls. Overweight men in the forskolin group experienced not only improved body composition (as measured by both body fat percentage and total fat mass), but also statistically significant increases in lean body mass. Coleus forskholii and more specifically, forskolin achieves this effect by rapidly, potently, and dose-dependently increasing an important metabolic enzyme known as adenylate cyclase. Adenylate cyclase is an enzyme responsible for catalyzing the formation of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP). This increase in cAMP formation eventually leads to the activation of an enzyme, protein kinase A, which in turn will phosphorylate and hence activate the enzyme, Hormone Sensitive Lipase (HSL) the rate-limiting enzyme necessary for stored triglycerides within adipocytes to be released as free fatty acids and utilized for energy. In more basic terms, this means that forskolin quite literally frees up more fatty acids to be used as fuel for exercise more or less the perfect scenario in a product such as Core SHRED!\u003c\/p\u003e\n\u003ch3\u003eCapsiAtra®:\u003c\/h3\u003e\n\u003cp\u003eCapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways most notably, those related to energy expenditure and lipid utilization.\u003c\/p\u003e\n\u003cp\u003eCapsiAtra® is a dihydrocapsiate compound naturally found in CH-19 Sweet peppers. Like several other capsinoids identified and extracted from pepper species, CapsiAtra® has demonstrated potent effects on several physiological pathways most notably, those related to energy expenditure and lipid utilization.\u003c\/p\u003e\n\u003cp\u003eThe thermogenic and lipolytic effects of capsinoids, like capsaicin itself, are mediated by the Transient Receptor Potential Vanilloid 1 (TRPV1) receptors in the mouth and throughout the gastrointestinal tract. TRPV1 receptors in the gut are linked with the sympathetic nervous system (SNS). When activated, they increase SNS activity (the figure below). TRPV1 receptors present on the tongue and in the oral cavity are responsible for, among other things, detection of thermal heat. When capsaicin binds to oral TRPV1 sites, one feels the sensation of heat and pungency. Capsinoids also stimulate TRPV1 receptors, but their effect is primarily on receptors in the throat and gut, not the mouth. Owing to the structural differences from capsaicin, the capsinoids are unable to reach the TRPV1 receptors on the tongue, which are located slightly below the mucosal surface. As a result, capsinoids do not produce the oral sensation of heat or the pungent taste associated with chili peppers, but they do produce the capsaicin like SNS response once they bind to TRPV1 receptors in the throat and gut.\u003c\/p\u003e\n\u003cp\u003eThe capsinoids have multiple biological functionalities. The sports nutrition properties are directly linked to their use in energy manipulation. The capsinoids have three principal mechanisms of action. First, they up-regulate UCP-3 (Mitochondrial Uncoupling Protein-3) in muscle cells. This causes ATP production to be dissociated with the respiration occurring in the mitochondria. This energy is then released as heat: an effect that is mirrored in caloric restriction as a means to economize energy. Second, they up-regulate UCP-1 (Uncoupling Protein-1, aka Thermogenin). This protein is only expressed in brown adipose tissue and is used to generate non- shivering thermogenesis; a process that evolved to protect against hypothermia. The up-regulation of UCP-1 can positively affect fat utilization and improve insulin sensitivity of tissues. Third, the capsinoids stimulate lipolysis via hydrolysis of triglycerides into glycerol plus three fatty acids. The release of these free fatty acids into the circulation is key to the energy regulating properties of the compound. Allowing these to become readily available as energy sources during exercise means that oxidation of muscle glycogen can be delayed, resulting in significant improvements in endurance.\u003c\/p\u003e\n\u003ch3\u003eGrains of Paradise Extract (12.5% 6-paradol):\u003c\/h3\u003e\n\u003cp\u003eAframomum melegueta, more commonly known as Grains of Paradise, or the alligator pepper, is a plant in the Ginger (Zingiberaceae) family. While complete compositional analysis has not been performed on Grains of Paradise, preliminary assays demonstrate is structural and chemical similarity to ginger principally in that both ginger and grains of paradise contains a range of pungent bioactives, one of which is 6-paradol.\u003c\/p\u003e\n\u003cp\u003eAlong with 6-shogaol, 6-paradol appears to be the most bioactive of the approximately 14 pungent compounds identified in ginger. Both compounds appear to potently and dose dependently mediate the PI3K (phosphoinositide 3-kinase)\/PKB (protein kinase B), leading specifically to an increase in AMPk phosphorylation. Known as the ‘master regulatory switch,’ AMPk is responsible for balancing endergonic (energy absorbing) and exogenic (energy liberating) processes in the body’s response to energy demands. AMPk is therefore heavily involved in adipocyte (fat cell) differentiation, proliferation, and hypertrophy, via regulating both enzymatic action (11B-HSD1, HSL, SREBP-1) and downstream lipogenic genes such as PPARy2.\u003c\/p\u003e\n\u003cp\u003eIn the case of gingerols such as 6-paradol, increased phosphorylation of AMPk in adipocytes appears to have a mitigating effect on hypertrophy by reducing lipid synthesis. 6-paradol appears to increase AMPk, which in turn decreases the mRNA expression of the downstream PPARy2 (peroxisome proliferate activated receptor gamma 2), a nuclear receptor gene principally responsible for lipid accumulation. In other words, the gingerols control a compound (AMPk) which, in turn, controls fat mass metabolism.\u003c\/p\u003e\n\u003ch3\u003ePro-GBB™ (Gamma Butyrobetaine Ethyl Ester HCL):\u003c\/h3\u003e\n\u003cp\u003eCore SHRED is using the trademarked form of Gamma Butyrobetaine Ethyl Ester HCL, or GBB for short, Pro-GBB™. GBB is a naturally occurring molecule in the body that aids in the boosting of the non-essential amino acid L-carnitine. L-carnitine plays a key role in energy production by its ability to transport fatty acids into the cell’s mitochondria (‘energy producing powerhouse’) to be used for energy. Studies have shown that when GBB is present it can increase the body's L-carnitine supply, thus providing enhanced benefits. So, in simplified terms, GBB increases usable L-carnitine in the body which increases the mitochondria’s ability to use fatty acids for energy. With the goal of reducing body fat or even improving performance, L-carnitine shows particular benefits in this field. A study conducted on mammals looked at the responses of L-carnitine supplementation on growth performance as well as circumference measurements. The results showed that the weight of muscle tissue increased, whereas abdominal fat percentage decreased.\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"50 Servings \/ Pineapple Strawberry","offer_id":17460324827194,"sku":"1005234","price":39.99,"currency_code":"USD","in_stock":false},{"title":"50 Servings \/ Tropic Heat","offer_id":31954862243898,"sku":"1005249","price":39.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/products\/core-nutritionals-core-shred-1005249-210041.jpg?v=1701816862"},{"product_id":"nutrakey-nac","title":"Nutrakey NAC","description":"\u003ch1 style=\"text-align: center;\"\u003eNutrakey | NAC\u003c\/h1\u003e\n\u003cdiv class=\"table table_pad\"\u003e\n\u003cdiv class=\"table-cell\"\u003e\n\u003ch2 title=\"#title\"\u003ePOWERFUL ANTIOXIDANT\u003c\/h2\u003e\n\u003cp\u003eN-Acetyl-L-Cysteine (NAC) has been shown in numerous studies to support healthy liver function. NAC and Methionine are two aminos well known for their ability to enhance Glutathione products in the liver. Glutathione is a major antioxidant that plays an essential role in liver detoxification. NAC provides powerful immune support and also packs a powerful anti-toxin potential because of its ability to neutralize cell and DNA damaging free radicals.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"table table_pad\"\u003e\n\u003cdiv class=\"table-cell fact_left_cell\"\u003e\n\u003ch2 title=\"#title\"\u003eSUPPORT TOXIN REMOVAL\u003c\/h2\u003e\n\u003cp\u003eAntioxidants protect your healthy cells from harmful free radicals. Free radicals are molecules that can cause damage to healthy cells and more them unable. Promote healthy liver function. Protect against free-radicals. Support toxin removal. Healthy regeneration.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Nutrakey","offers":[{"title":"60 Capsules","offer_id":17531876769850,"sku":"6150053","price":14.7,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/products\/nutrakey-nac-6150053-121469.png?v=1701817384"},{"product_id":"core-nutritionals-abcd-bcaa-energy","title":"Core ABCD BCAA + Energy","description":"\u003cp\u003e\u003cimg alt=\"Core ABCD Banner\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/files\/core-abcd-banner_compressed.jpg?v=1599074252\"\u003e\u003c\/p\u003e\n\u003cp\u003eAmino acid products with a caffeine or energy component are very popular these days. There’s only one problem: almost none of them contain a solid serving of amino acids, and most don’t contain BCAAs at all! Don’t get us wrong, we love EAAs – but when you think “amino acid product,” are you really thinking cysteine? Us neither.\u003c\/p\u003e\n\u003cp\u003eSo, in classic Core style, we did something about it: we created Core ABCD, the amino and caffeine product with actual BCAAs, at a full serving size. But we of course didn’t stop there. We included CarnoSyn® beta-alanine, to provide you muscle energy and endurance – along with the caffeine in our Drive™ energy blend. We included N-Acetyl-Tyrosine for all its important roles in metabolism and neurohormone production. We included Acetyl-L-Carnitine, to keep that carbohydrate and fat metabolism rolling. And of course, we included not only caffeine (which all the other guys do), but also choline bitartrate – to enhance focus along the way.\u003c\/p\u003e\n\u003cp\u003eCore ABCD is the premier and most complete product in its category, hands down. No product of its type offers as much for such little cost: it’s an energy product, an endurance product, and a complete amino acid product all in one.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eBranched-Chain Amino Acids\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eIf one were to think of the body as a construction project, amino acids would be the most basic building materials: raw lumber, mortar, bricks, and so on. While the assembly of these building blocks is of course critically important to the function of the building – and one of the amino acids, leucine, controls its own assembly – the quality and availability of the materials themselves is arguably more important. Not enough concrete? The foundation cracks and the building falls.\u003cbr\u003e\u003cbr\u003eYour body is the exact same way. It is comprised of various amino acids, both essential and non-essential, that comprise the cellular basis of each and every cell in your body. When it comes down to skeletal muscle, the three most important are known as the BCAAs – or branch chained amino acids. Comprised of leucine, isoleucine, and valine, these three little amino acids effectively control the rate at which your muscle grows (hypertrophies), its contractile force, its endurance, and so on – to say they are massively important is an understatement. For this reason, they form the basis of any competently-designed supplement protocol.\u003cbr\u003e\u003cbr\u003eCollectively, as stated above, the branch-chained amino acids leucine, isoleucine, and valine are famous for their role in skeletal muscle protein synthesis and metabolism, and additionally comprise approximately one-third of all skeletal muscle protein. Of the three, leucine is both the most physiologically important with respect to muscle mass, and the most extensively studied. Data on leucine demonstrate this amino acid plays critical roles in stimulating skeletal muscle protein synthesis, and ribosomal biogenesis and assembly (the literal building of muscle tissue), along with playing a lesser role in insulin signaling and gluconeogenic processes. As a result of these diverse roles, leucine has been demonstrated to significantly stimulate skeletal muscle protein synthesis, and attenuate protein degradation, by both insulin-mediated and non-insulin mediated mechanisms.\u003cbr\u003e\u003cbr\u003eLeucine’s insulin-mediated effects are largely the result of its activation of the classical insulin receptor substrate (IRS)\/phosphatidylinositol (PI) 3-kinase (PI3K)\/Akt\/mTOR signal transduction pathway. In this pathway, the bonding of a substrate (glucose) eventually activates a compound known as Akt. Once phosphorylated and activated, Akt signals the release of the famous mammalian target of rapmycin (mTOR). mTOR then increases the translation of muscle-cell ribosomal proteins that increase ribosome biogenesis, which is the literal production of proteins. Leucine has additionally been shown to positively regulate protein synthesis independent of insulin. In certain trials where rapamycin and leucine were co-administered, rapamycin showed only partial inhibition of leucine’s effects on muscle protein synthesis.\u003cbr\u003e\u003cbr\u003eIn more practical terms, there is a significant body of evidence demonstrating the positive effect of BCAA’s on athletic performance. Extensive studies in exercise-trained populations reveal that, collectively, BCAA’s may:\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eReduce total muscle soreness after intense resistance training, and\/or further delay its onset.\u003c\/li\u003e\n\u003cli\u003eDecrease muscle recovery time between bouts of intense resistance exercise training.\u003c\/li\u003e\n\u003cli\u003eIncrease lean body mass when used daily, in conjunction with diet and exercise.\u003c\/li\u003e\n\u003cli\u003eWhile products with larger BCAA ratios (ratio of leucine, to isoleucine, to valine) have recently flooded the market, Core Nutritionals has remained with the gold standard of 2:1:1. This decision is made in recognition of the fact that, for all its potential benefits, there is no evidence demonstrating a realized effect of a larger BCAA ratio – and in fact, all the benefits mentioned above derive from evidence using the gold standard 2:1:1 ratio.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eCarnoSyn® Beta-Alanine\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eCarnosine is a bit of an odd duck: we know that it is crucial for muscle function and that dietary sources of carnosine are essential, but we don’t know precisely how it's working. Moreover, for decades, we had no idea how to increase intramuscular concentrations, as exogenous carnosine sources degraded in the body so fast as to be effectively useless. \u003cbr\u003e\u003cbr\u003eEnter beta-alanine. Simply a different iteration of one of the amino acids that comprises carnosine itself (alanine), beta-alanine has proven to be the most effective means of significantly increasing intramuscular concentrations of carnosine – and therefore of promoting all of carnosine’s various beneficial effects on muscle performance. If that weren’t enough, beta-alanine has also demonstrated beneficial physiological effects independent of its parent compound. In order to understand why, though, we need to first understand some of the basics behind carnosine itself. \u003cbr\u003e\u003cbr\u003eCarnosine, a cytoplasmic dipeptide synthesized from the precursors L-histidine and l-alanine, is present in high concentrations in skeletal muscle and plays a pivotal role as a “chemical buffer” in myocytes (muscle cells). It has long been known that carnosine concentrations are highest in glycolytic, rather than oxidative muscle fibers (roughly speaking, explosive vs., endurance muscle fibers, respectively), and thus long hypothesized that this amino acid is required for sustained performance during supramaximal exercise. Recent research demonstrates that carnosine exerts its physiological effects in long hypoxic (low oxygen) drives by functioning as a high-capacity pH buffer in skeletal muscle, preventing the pH ratio of plasma from dropping too low – and therefore preventing crucial pH-dependent processes such as protein synthesis from being inhibited by acidosis. \u003cbr\u003e\u003cbr\u003eDespite its critical role in skeletal muscle anaerobic performance, intramyocellular synthesis of carnosine is rate-limited by the availability of l-alanine. Unfortunately, the majority of literature demonstrates that attempting to increase intramuscular levels of carnosine via either direct carnosine or alanine supplementation is largely ineffective due to carnosine\/alanine pharmacokinetics. Enter beta-alanine. Research with beta-alanine demonstrates consistent and dose-dependent increases to intramuscular carnosine concentrations with beta-alanine supplementation, with certain studies showing an increase of 40-60% with chronic administration. These same literature reveal a synergistic effect of exercise on beta-alanine supplementation, whereby the muscle adaptive changes associated with resistance training promote further intramuscular carnosine production in response to beta-alanine supplementation.\u003cbr\u003e\u003cbr\u003eIn simpler language, this essentially means that beta-alanine is a dietary supplement that promotes its own effects in combination with exercise. As you exercise, you simultaneously intensify beta-alanine’s physiological actions – both directly, as well as in the production of intramuscular carnosine. Once ingested, beta-alanine’s exercise-specific beneficial activity is well-established. Elevation of intramuscular carnosine content via beta-alanine supplementation has been show to improve performance in the following ways:\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003eBoth acute and chronic increases in total work capacity, measured by total volume during exercise sessions.\u003c\/li\u003e\n\u003cli\u003eHighly significant increases to TTE (total time to exhaustion), one of the most accurate and comprehensive measures of endurance. In various trials, beta-alanine supplementation has been shown to increase TTE by upwards of 20%.\u003c\/li\u003e\n\u003cli\u003eIncreases to total muscle power output in both acute and chronic trials, suggesting that beta-alanine’s most significant benefit is to those engaging in power-dependent resistance training.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eIn total, a significant body of research exists to suggest that beta-alanine may significantly increase muscle power output, strength, training volume and output, overall performance in hypoxic (oxygen-deprived) conditions, and peak VO2 max (oxygen holding capacity).\u003cbr\u003e\u003cbr\u003eThese myriad benefits make beta-alanine both one of the most-studied, and most well-rounded dietary supplements. Beta-alanine not only has direct, actionable physiological effects, but also promotes critical muscle physiologic adaptations that promote its own effects.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eAcetyl-L-Carnitine\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eAcetyl-L-carnitine has been shown to:\u003cbr\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003ePromote fatty acid and carbohydrate metabolism\u003c\/li\u003e\n\u003cli\u003eBe involved in brain processes such as mood and memory\u003c\/li\u003e\n\u003cli\u003ePlay a key role in protein synthesis\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eAcetyl-L-Carnitine (ALCAR) is a little bit like your 401K: you need it, you know you should pay attention to it, but it’s not exactly the sexiest topic. We know; we feel you! But we also know that ALCAR is one of the most fascinating, useful, and physiologically exciting workout supplements on the planet. You’re hard-pressed to find a single other ingredient that is involved in so many critical bodily processes: fatty acid and carbohydrate metabolism, neurotransmission, exercise performance and capacity, brain function – the list goes on! So, like your 401K contribution, don’t forget to pay into your ALCAR fund. \u003cbr\u003e\u003cbr\u003eL-carnitine is a derivative of the amino acid lysine and, as certain conditions outpace the body’s ability to produce it, l-carnitine is considered a conditionally essential amino acid. While endogenous biosynthesis of l-carnitine from the amino acids lysine and methionine is sufficient for essential processes – along with dietary sources of carnitine from protein-rich red meat, for example – dietary supplementation of carnitine may pose benefits in certain physiological conditions. \u003cbr\u003e\u003cbr\u003eUnfortunately, due to excess metabolism of l-carnitine by microorganisms in the small intestine, exogenous supplementation with oral l-carnitine has proved ineffective. ALCAR, an acetylated version of l-carnitine, has considerably higher oral bioavailability, due likely to only partial hydrolytic metabolism. Once in the bloodstream, ALCAR plays a fundamental role in the production of energy, acting as the catalyst for the beta-oxidation of long-chain fatty acids by the mitochondria; regulating the CoA to Acyl-CoA ratio (necessary for the production of ATP); and the metabolism of carbohydrates. ALCAR also is an excitatory agent for neurons, increases neuronal transmission, and increases the production of neurotransmitters and neurohormones such as dopamine and serotonin.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eN-Acetyl-Tyrosine\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eTyrosine is amongst a class of amino acids known as ‘non-essential’ amino acids, so-called because the body can produce them endogenously, and it is therefore not essential to consume dietary tyrosine. That said, tyrosine is also what is known as a conditionally essential amino acid; conditionally-essential because, along with glucose and ammonia, the synthesis of tyrosine additionally requires adequate levels of phenylalanine. Once synthesized, tyrosine is one of the most critical amino acids, given its prominent role as a substrate in the synthesis of the catecholamines dopamine, norepinephrine, and epinephrine, in addition to both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones.\u003cbr\u003e\u003cbr\u003eIn studies on stress modulation, tyrosine has been demonstrated to reverse stress-induced norepinephrine depletion and the depressant-behavioral effects normally associated with it. In simpler terms, tyrosine may, in certain conditions, dampen the extent to which norepinephrine is removed from the bloodstream during a stress event. In simpler terms still, tyrosine may help to mitigate the sense of depletion and fatigue felt at the end of a workout.\u003cbr\u003e\u003cbr\u003eTyrosine may also play important metabolic functions, mostly related to its role in synthesizing compounds that stimulate the nervous system. While not traditionally considered a sympathomimetic amine, studies which have coadministered tyrosine and stimulants demonstrate a synergistic effect. These studies suggest that tyrosine may potentiate the effects of both endogenous and supplemental norepinephrine and its mimetics (in the case of exogenous use) with respect to lipolysis, thermogenesis, and energy expenditure. Meaning that tyrosine may play a role in assisting norepinephrine to break up triglycerides and increase body heat transiently.\u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eCholine Bitartrate\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eCholine is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for a number of functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator is partially responsible for modulating risk\/reward, arousal, and enhancing memory.\u003cbr\u003e\u003cbr\u003eCholine’s essential role as a substrate for acetylcholine, and therefore brain development, is well documented in animal models. These studies demonstrate that levels of free maternal choline have a direct and fundamental impact on prenatal brain development, with the enhancements or deficits lasting into adulthood. Choline’s enhancing effect is particularly prominent in the hippocampus. In humans, the hippocampus is primarily involved in the consolidation of memory (taking short, episodic memory and translating it into long-term memory) and the learning of new information. Acetylcholine is a critical component in these processes, as mentioned above, and choline may therefore play a potential role in these processes as well by providing the substrate for acetylcholine synthesis.\u003cbr\u003e\u003cbr\u003eTartaric acid occurs naturally in the food source, while its salt derivatives (tartrate, for example) have been used as acidulants, antioxidant synergists, buffers, and sequestrants. As free base choline is rapidly destroyed in metabolism, attaching a salt to enhance absorption is necessary. The bitartrate salt addition preserves choline from being destroyed during metabolism. \u003cbr\u003e\u003cbr\u003e\u003cstrong\u003eCaffeine Anhydrous\u003c\/strong\u003e\u003cbr\u003e\u003cbr\u003eCaffeine is one of the most widely consumed, and perhaps some of the most reviewed, psychoactive compounds. Their physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities.\u003cbr\u003e\u003cbr\u003eMost importantly to Core ABCD, caffeine has been shown to have significant effects on exercise performance, even with ingestion in servings as small 3 to 9mg\/kg\/bw\/day (the equivalent of 2 cups of standard coffee, for a 170lb male). In endurance training, possible explanations for caffeine’s performance-enhancing effects lie in its metabolic effects on both lean and fat tissue. It is suggested that caffeine’s potent lipolytic (the breakdown of fat tissue into fatty acids) and oxidative (the actual ‘burning’ of fat) action allow the body to utilize these sources during prolonged submaximal exercise. As a consequence, muscle glycogen is spared and available for use later in the training session. Practically speaking, this means caffeine is forcing your body to preferentially use fat tissue as a fuel source while sparing the glycogen which gives you the full-bodied look!\u003cbr\u003e\u003cbr\u003eIn short-term exercise, caffeine’s demonstrated role in the inhibition of cyclic AMP- phosphodiesterases (PDE), adenosine receptor antagonism, and adrenoreceptor agonism come into play. These three pathways collectively stimulate lipolytic activity, boost fat metabolism, increase metabolic rate and energy expenditure, and regulate the body’s thermogenic activity. The practical results of activating these pathways are increases to the contractile force of both cardiac and skeletal muscle (harder flexion), an increase in energy expenditure (freeing up more caloric energy to be used in contraction), dilation of the vasculature (better blood flow), and improvements to both nitrogen retention and skeletal muscle protein synthesis (key components to muscle building).\u003c\/p\u003e","brand":"Core Nutritionals","offers":[{"title":"Sweet Tea","offer_id":22786845147194,"sku":"1003345","price":29.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/products\/core-nutritionals-core-abcd-bcaa-energy-1003142-842267.jpg?v=1701816859"},{"product_id":"now-foods-l-cysteine","title":"NOW Foods L-Cysteine 500mg","description":"\u003cp data-start=\"651\" data-end=\"1008\"\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eNOW \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eFoods 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class=\"BZ_Pyq_fadeIn\"\u003ecysteine \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ealso \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003econtributes \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eto \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ethe \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eproduction \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eof \u003c\/span\u003e\u003cstrong data-start=\"1059\" data-end=\"1074\"\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eglutathione\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e, \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eone \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eof \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ethe \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ebody’s \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003emost \u003c\/span\u003e\u003cspan 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class=\"BZ_Pyq_fadeIn\"\u003epurity, \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003epotency, \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eand \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003econsistency\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr data-start=\"1610\" data-end=\"1613\"\u003e\n\u003ch2 data-section-id=\"17xbmye\" data-start=\"1615\" data-end=\"1630\"\u003e\u003cstrong\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eKey \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eBenefits\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"1632\" data-end=\"1910\"\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e• \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eSupports \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ekeratin \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eproduction \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003efor \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ehair, \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eskin, \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eand \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003enails\u003c\/span\u003e\u003cbr data-start=\"1688\" data-end=\"1691\"\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e• \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eContributes \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eto \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eantioxidant \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eactivity \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ethrough \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eglutathione \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eproduction\u003c\/span\u003e\u003cbr data-start=\"1760\" data-end=\"1763\"\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e• 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data-start=\"1936\" data-end=\"2041\"\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eTake \u003c\/span\u003e\u003cstrong data-start=\"1941\" data-end=\"1973\"\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e1 \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ecapsule \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e1 \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eto \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e3 \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003etimes \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003edaily\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003e, \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003epreferably \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ewith \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003efood, \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eor \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eas \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003edirected \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eby \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ea \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003ehealthcare \u003c\/span\u003e\u003cspan class=\"BZ_Pyq_fadeIn\"\u003eprofessional.\u003c\/span\u003e\u003c\/p\u003e","brand":"NOW Foods","offers":[{"title":"100 Tablets","offer_id":39391941165114,"sku":"0077","price":13.46,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/files\/33_2.avif?v=1759508866"},{"product_id":"now-foods-l-methionine-500-mg-with-vitamin-b-6-amino-acid-support","title":"NOW Foods L-Methionine 500 mg with Vitamin B-6","description":"\u003cp data-start=\"767\" data-end=\"1074\"\u003eNOW Foods \u003cstrong data-start=\"777\" data-end=\"817\"\u003eL-Methionine 500 mg with Vitamin B-6\u003c\/strong\u003e provides a high-quality amino acid formula designed to support normal metabolic processes and detoxification pathways in the body. L-Methionine is an essential sulfur-containing amino acid that plays a key role in protein synthesis and cellular metabolism.\u003c\/p\u003e\n\u003cp data-start=\"1076\" data-end=\"1348\"\u003eL-Methionine also participates in the production of important compounds involved in normal metabolic function. This formula is enhanced with \u003cstrong data-start=\"1217\" data-end=\"1232\"\u003eVitamin B-6\u003c\/strong\u003e, an essential nutrient that supports amino acid metabolism and helps the body efficiently utilize dietary proteins.\u003c\/p\u003e\n\u003cp data-start=\"1350\" data-end=\"1474\"\u003eTogether, L-Methionine and Vitamin B-6 work to support healthy metabolic activity as part of a balanced nutritional routine.\u003c\/p\u003e\n\u003cp data-start=\"1476\" data-end=\"1704\"\u003eNOW Foods manufactures this supplement under strict quality standards to ensure purity, potency, and consistency. The formula is \u003cstrong data-start=\"1605\" data-end=\"1645\"\u003eNon-GMO and suitable for vegetarians\u003c\/strong\u003e, providing a reliable amino acid supplement for daily use.\u003c\/p\u003e\n\u003chr data-start=\"1706\" data-end=\"1709\"\u003e\n\u003ch2 data-section-id=\"17xbmye\" data-start=\"1711\" data-end=\"1726\"\u003e\u003cstrong\u003eKey Benefits\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli data-start=\"1730\" data-end=\"1774\"\u003eProvides \u003cstrong data-start=\"1739\" data-end=\"1774\"\u003e500 mg L-Methionine per capsule\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1777\" data-end=\"1820\"\u003eSupports \u003cstrong data-start=\"1786\" data-end=\"1820\"\u003enormal detoxification pathways\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1823\" data-end=\"1873\"\u003eIncludes \u003cstrong data-start=\"1832\" data-end=\"1873\"\u003eVitamin B-6 for amino acid metabolism\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli data-start=\"1876\" data-end=\"1907\"\u003eEssential amino acid supplement\u003c\/li\u003e\n\u003cli data-start=\"1910\" data-end=\"1944\"\u003eConvenient \u003cstrong data-start=\"1921\" data-end=\"1944\"\u003evegetarian capsules\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr data-start=\"1946\" data-end=\"1949\"\u003e\n\u003ch2 data-section-id=\"1cv6nhx\" data-start=\"1951\" data-end=\"1975\"\u003e\u003cstrong\u003eWhat Is L-Methionine?\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"1977\" data-end=\"2216\"\u003eL-Methionine is an \u003cstrong data-start=\"1996\" data-end=\"2020\"\u003eessential amino acid\u003c\/strong\u003e, meaning it must be obtained through diet or supplementation. It plays a role in protein synthesis and participates in metabolic pathways that support the body’s natural detoxification processes.\u003c\/p\u003e\n\u003cp data-start=\"2218\" data-end=\"2331\"\u003eVitamin B-6 helps support normal amino acid metabolism and assists the body in utilizing amino acids efficiently.\u003c\/p\u003e\n\u003chr data-start=\"2333\" data-end=\"2336\"\u003e\n\u003ch2 data-section-id=\"apzncz\" data-start=\"2338\" data-end=\"2356\"\u003e\u003cstrong\u003eSuggested Use\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cp data-start=\"2357\" data-end=\"2425\"\u003eTake \u003cstrong data-start=\"2362\" data-end=\"2392\"\u003e2 capsules daily as needed\u003c\/strong\u003e, preferably on an empty stomach.\u003c\/p\u003e\n\u003chr data-start=\"2427\" data-end=\"2430\"\u003e\n\u003ch2 data-section-id=\"1acwf17\" data-start=\"2432\" data-end=\"2456\"\u003e\u003cstrong\u003eSupplement Highlights\u003c\/strong\u003e\u003c\/h2\u003e\n\u003cul\u003e\n\u003cli data-start=\"2460\" data-end=\"2493\"\u003e500 mg L-Methionine per capsule\u003c\/li\u003e\n\u003cli data-start=\"2496\" data-end=\"2518\"\u003eIncludes Vitamin B-6\u003c\/li\u003e\n\u003cli data-start=\"2521\" data-end=\"2555\"\u003eSupports detoxification pathways\u003c\/li\u003e\n\u003cli data-start=\"2558\" data-end=\"2581\"\u003eAmino acid supplement\u003c\/li\u003e\n\u003cli data-start=\"2584\" data-end=\"2593\"\u003eNon-GMO\u003c\/li\u003e\n\u003cli data-start=\"2596\" data-end=\"2617\"\u003eVegetarian capsules\u003c\/li\u003e\n\u003cli data-start=\"2620\" data-end=\"2647\"\u003eQuality tested by NOW Foods\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"NOW Foods","offers":[{"title":"100 Veg Capsules","offer_id":41283229581370,"sku":"0117","price":16.95,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0133\/8576\/0826\/files\/NOWFoods_L-Methionine_100VegCapsules.png?v=1773152891"}],"url":"https:\/\/tigerfitness.com\/collections\/l-methionine.oembed","provider":"Tiger Fitness","version":"1.0","type":"link"}